USP Apparatus 4 Automated Flow-through Dissolution System

SUPER-4 Flow-through System is a precision 8-channel USP Apparatus 4 flow-through system that is automation-ready with the DSC-800 autosampler/controller, SCR-DL sample collector and MC-4000 media changer.

Brochure (please click to download): SUPER-4 Flow-through System

Applications

• Dissolution or release testing of tablets, capsules, suppositories, stents, implants, microspheres, suspensions, liposomes and more
• Ideal for poorly soluble dosage forms

Features

• Run in open or closed loop mode
• Waterbath design ensures excellent cell-to-cell temperature uniformity
• Independent in-cell sensors for real time media temperature monitoring
• Collect in test tubes or HPLC vials
• Run up to four independent flow rates during same run for method development
• Constant flow mode and pulsation mode options
• Use one or multiple stacked filters to prevent clogging
• Heated media delivery lines ensure temperature stability throughout the run
• Supports media changes up to four different pH values with buffering
• Store up to 20 methods
• A wide variety of flow-through cell options such as 22.6 mm large cell, 12 mm small cell, powder cell, suppository cell, gel cell, transdermal cell, etc.
• 21 CFR Part 11, USP, EP, JP, CP compliant

Extended Functions

• Compatible with on-line UV/ HPLC to perform online dissolution analysis
• Compatible with PERMETRO system to distinguish between the permeation of generic drugs and original drugs, for BE/BA studies